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The ones who run this laboratory
Hi and welcome! I’m the Sanders Lab head and an independent group leader at the Berlin Institute for Medical Systems Biology (BIMSB) at the MDC. We apply single cell genomic technologies to biomedical and translational problems. My lab’s research broadly aims to (1) develop new and innovative single cell technologies that combine experimental and computational methods to explore germline and somatic genetic variation with a new lens, and (2) apply these methods to investigate how genetic mutations arise in our cells and tissues, how they impact cell states and functions, and how they contribute to human health and disease. I love finding new applications, building strong collaborations and pushing the edge of discovery. I also love yoga and mountains. Happy research!
I’m a new PhD student and my research interest is in Molecular Biology, Cellular Biology and in particular in the deviation of Cellular Mechanisms from healthy to disease. I’m currently looking at Somatic Mosaicism and Genomic Mutations at a single-cell level in autoinflammatory disease, in collaboration with clinicians. Happy research!
General lab manager and hands-on work, supporting the single cell research area. Happy research!
Hi there! I'm a young scientist with a general interest in Molecular Biology, Genetics and Autoimmunity. I recently joined the Sanders Lab at the Max-Delbrück-Center for Molecular Medicine (MDC) at the Berlin Institute for Medical Systems Biology (BIMSB) as a PhD student in the "Single cell approaches for personalized medicine" focus group. I investigate how somatic mosaicism contributes to tissue homeostasis and human disease. Happy research!
Hello!! I’m a PhD student with research interests in stem cell biology and personalized medicine. I’m working on developing a framework to evaluate genomic stability and clinical safety of using iPSC derived cells for personalised medicine. Happy research! :)
I'm a computational PhD student aiming to build bioinformatic pipelines to study somatic mutations in single cells. Happy research!
With a background in sociolinguistics and public relations I provide administrative and organizational support to the Sanders Lab. Happy research!
Hi!! I’m Tobi - a master’s student in the Sanders Lab! I have a keen interest in Molecular and Cell Biology. For my thesis, I will investigate drug effects on genomic mutations in organoid cultures. Happy research!
Single cells and raw BANERGEE.
Hi there! I’m a PhD student interested in the heterogeneity of B(est) cell functions in autoimmune diseases such as Systemic Lupus Erythematosus (SLE). I will apply genomic and transcriptomic tools at a single-cell level to detect somatic mutations that may play a role in the pathophysiology of lupus. Happy research!
Hello! I’m Chiara - a master student in the Sanders Lab! I have a keen interest in human genetics, specifically in investigating somatic mutations and their potential functional consequences. As part of my thesis I will generate a nucleosome occupancy atlas of human immune cells. Happy research!
Key features of our laboratory
During normal development and ageing the cells in our body can acquire somatic mutations through diverse genome instability processes. These mutations are propagated and selected for over time. As consequence, we are actually a mosaic of unique somatic cell genomes, where any given cell in a tissue may be genetically distinct from another.
Understanding how somatic mosaicism develops and evolves are central questions in the Sanders laboratory. With a focus on the genome, we develop and apply innovative single cell methods that explore the mechanisms of genome instability to understand how mutations arise and change cellular phenotypes in normal human tissues and disease states.
By integrating multi-omic experimental and computational readouts, we ask how individual cells differ in terms of their unique genomic profiles, epigenetic programs and transcriptional outputs, and directly test the functional outcomes of somatic mutations to understand how they contribute to tissue homeostasis and human disease.
We push the boundaries of whats known through the developement and application of single-cell technologies in translational medicine. We believe in good scientific practice and enforce open and transparent workflows in all aspects of our work.
We love what we do and comprise an interdisciplinary team of highly motivated young scientists from all around the world. While doing great science together is a top priority, it is just as important to us to look after each other and create an inclusive work environment everybody feels welcomed in.
We enforce transparency and facilitate coorperation by making our pipelines and code publicly available through our github depository. Visit our resource section to learn more about our code depository and usefull links to tutorials to help you get started with your single cell analysis! If you have questions don't hesitate to contact us!
Communication inside and outside of the scientific community nowadays is more important than ever with people questioning the scientific method and misinformation on the rise. We aim to contribute to a better society by publishing and discussing our research through scientific journals as well as social media and hope to inspire future generations of scientists. Follow us on our Instagram and Twitter!
Single cell goes clinical!
We are part of the
"Single Cell Technologies for Personalized Medicine" focus group at the
Berlin Institute for Medical Systems Biology (BIMSB)
Max-Delbrück-Centre for Molecular Medicine in the Helmholtz Association (MDC)
and cooperate with a multitude of great scientific institutes across
The focus group was jointly launched by the Berlin Institute of Health (BIH) , the BIMSB, as well as the Charité – Universitätsmedizin Berlin and aims to use innovative single-cell technologies to answer clinical research questions. Together with our colleagues in the AG Ludwig, AG Grosswendt and AG Haas , we started our laboratories in January 2021. Through our Institute in the heart of Berlin, we have access to the latest single-cell methods and can collaborate with excellent systems biologists.
Explore our contributions or follow us on social media
Sanders Lab and friends!
Explore our peer-reviewed research projects
Full Publication List
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